Clinical and hematological status of dogs with combined liver and kidney pathology
DOI:
https://doi.org/10.31210/spi2025.28.04.28Keywords:
diagnostics, dogs, liver, kidneys, combined pathology, clinical signs, erythrocytes, leukocytesAbstract
The results of studies are presented in the article on clinical signs and indicators of red blood cell count, hemoglobin content, hemoglobin saturation of red blood cells, as well as white blood cell count in the blood of domestic dogs with combined liver and kidney pathology. The study results of 37 spontaneously diseased animals with the signs of renal dysfunction, acute hepatitis, chronic hepatitis, hypertrophic cirrhosis of the liver, atrophic cirrhosis of the liver, and hepatolipidosis are presented. The aim of the study was to investigate the clinical status of dogs and separate hematological parameters in dogs with liver disease accompanied by nephropathy. The blood test results were statistically processed and compared with the parameters of ten clinically healthy dogs. It was found that the acute course of hepatitis in case of nephropathy was characterized by hyporexia, hepatomegaly, pain syndrome at palpation of the liver (100 %), polyuria, polydipsia (50–70 %), normochromic anemia (the number of red blood cells was 27.7, and the hemoglobin content was by 40.8 % lower compared to the results of clinically healthy animals). Chronic hepatitis was accompanied by hyporexia and depression (90–100 % of animals), thirst and polyuria (80 %), pain in the liver and kidneys at palpation, and the red blood cell count was by 21.5 % lower than that of clinically healthy dogs and hemoglobin – by 20.4 %. Hypertrophic cirrhosis of the liver was characterized by depression, exhaustion, hyporexia, vomiting, signs of nephropathy – polyuria, polydipsia, pain in the kidneys at palpation (80 %), hypochromic anemia (MCH 19.2±1.21 pg), and leukocytosis (14.0±0.79 G/l). Atrophic cirrhosis of the liver, in addition to the above mentioned signs, was accompanied by more pronounced clinical signs of nephrosis (dysuria, pain syndrome). Hepatolipidosis was not accompanied by characteristic signs of nephropathy and was characterized by sporadic hyporexia, anemia (P˂0.01), and leukocytosis (P˂0.05).
References
Kravchenko, S. O., Kanivets, N. S., & Rudiashko, V. S. (2025). Kliniko-laboratorni oznaky hepatopatii za KhKhN u sobak. Naukovi chytannia 2025. Veterynarna medytsyna i bioriznomanittia v tsyfro-vu epokhu: innovatsii, diahnostyka, zakhyst : materialy ХIІ shchorichnoi Vseukrainskoi naukovo-praktychnoi konferentsii naukovo-pedahohichnykh pratsivnykiv, aspirantiv ta mahistriv, prysviachena Dniu nauky v Ukraini, 20 travnia 2025 r. (83–85). Zhytomyr: Poliskyi natsionalnyi universytet [in Ukrainian]
Chikazawa, S., & Dunning, M. D. (2016). A review of anaemia of inflammatory disease in dogs and cats. Journal of Small Animal Practice, 57 (7), 348–353. https://doi.org/10.1111/jsap.12498
Czaja, A. J. (2016). Diagnosis and management of autoimmune hepatitis: Current status and future directions. Gut and Liver, 10 (2), 177–203. https://doi.org/10.5009/gnl15352
D’Amico, G., & Perricone, G. (2019). Prediction of decompensation in patients with compensated cirrhosis: Does etiology matter? Current Hepatology Reports, 18 (2), 144–156. https://doi.org/10.1007/s11901-019-00473-1
Egerod Israelsen, M., Gluud, L. L., & Krag, A. (2015). Acute kidney injury and hepatorenal syndrome in cirrhosis. Journal of Gastroenterology and Hepatology, 30 (2), 236–243. https://doi.org/10.1111/jgh.12709
Elhiblu, M. A., Dua, K., Mohindroo, J., Mahajan, S. K., Sood, N. K., & Dhaliwal, P. S. (2015). Clinico-hemato-biochemical profile of dogs with liver cirrhosis. Veterinary World, 8 (4), 487–491. https://doi.org/10.14202/vetworld.2015.487-491
Das, S., & Lodh, C. (2024). Diagnostic studies in canine hepatic cirrhosis. Indian Journal of Canine Practice, 16 (1), 028–032. https://doi.org/10.29005/ijcp.2024.16.1.028-032
Eulenberg, V. M., & Lidbury, J. A. (2018). Hepatic fibrosis in dogs. Journal of Veterinary Internal Medicine, 32 (1), 26–41. https://doi.org/10.1111/jvim.14891
Grimes, C. N., & Fry, M. M. (2014). Nonregenerative anemia. Veterinary Pathology, 52 (2), 298–311. https://doi.org/10.1177/0300985814529315
Hartleb, M. (2012). Kidneys in chronic liver diseases. World Journal of Gastroenterology, 18 (24), 3035. https://doi.org/10.3748/wjg.v18.i24.3035
Kashliak, N. O., & Vlizlo, V. V. (2023). Symptoms, biochemical indicators and general blood analysis for hepatopathy in dogs. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 25 (112), 193–200. https://doi.org/10.32718/nvlvet11230
Lane, K., Dixon, J. J., MacPhee, I. A. M., & Philips, B. J. (2013). Renohepatic crosstalk: does acute kidney injury cause liver dysfunction? Nephrology Dialysis Transplantation, 28 (7), 1634–1647. https://doi.org/10.1093/ndt/gft091
Lokes-Krupka, T. P., Vlokh, I. Yu., Baklytska, A. S., Kanivets, N. S., & Karysheva, L. P. (2022). Clinical case of chronic hepatitis in a domestic dog. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies, 24 (107), 94–99. https://doi.org/10.32718/nvlvet10716
McCown, J. L., & Specht, A. J. (2011). Iron homeostasis and disorders in dogs and cats: A review. Journal of the American Animal Hospital Association, 47 (3), 151–160. https://doi.org/10.5326/jaaha-ms-5553
Negasee, K. A. (2021). Hepatic diseases in canine and feline: A review. Veterinary Medicine – Open Journal, 6 (1), 22–31. https://doi.org/10.17140/vmoj-6-155
Rad, N. K., Heydari, Z., Tamimi, A. H., Zahmatkesh, E., Shpichka, A., Barekat, M., Timashev, P., Hossein-Khannazer, N., Hassan, M., & Vosough, M. (2024). Review on kidney-liver crosstalk: Pathophysiology of their disorders. Cell Journal, 26 (2), 98–111.
Vovkotrub, N., Melnyk, A.Y., Piddubnyak, O.V., Kharchenko, A., & Chub, O. (2022). Evaluation of changes in indicators of the liver and kidneys functional state in sheep under the influence of the drug "Аlphabet for animals". Naukovij Vìsnik Veterinarnoï Medicini, 2, 55–65. https://doi.org/10.33245/2310-4902-2022-176-2-55-65
Webster, C. R. L., Center, S. A., Cullen, J. M., Penninck, D. G., Richter, K. P., Twedt, D. C., & Watson, P. J. (2019). ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. Journal of Veterinary Internal Medicine, 33 (3), 1173–1200. https://doi.org/10.1111/jvim.15467
Weiss, G., Ganz, T., & Goodnough, L. T. (2019). Anemia of inflammation. Blood, 133 (1), 40–50. https://doi.org/10.1182/blood-2018-06-856500
Ziccardi, C., Cohn, L. A., Janacek, B., Gross, J., Nafe, L., & Grobman, M. (2022). Etiology and outcome of extreme neutrophilic leukocytosis: A multi-institutional retrospective study of 269 dogs. Journal of Veterinary Internal Medicine, 36 (2), 541–548. https://doi.org/10.1111/jvim.16344
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