Economic and therapeutic efficacy of specific and complex therapy of dogs for cystoisosporiasis
DOI:
https://doi.org/10.31210/spi2026.29.02.20Keywords:
canine cystoisosporiasis, treatment, economic efficiency, medicinesAbstract
Measures to control canine cystoisosporiasis must be implemented complexly, where one of the criteria for their efficacy is the correct choice of the necessary treatment methods, as well as their economic expediency. For this purpose, scientists use a certain range of anti-parasitic preparations, which have different composition, method of application, duration of action, different effectiveness and cost. The aim of the research was to establish the economic and therapeutic efficacy of the specific and complex therapy of dogs with spontaneous cystoisosporiais. In experimental conditions, specific preparations of domestic production “Turil® 5%” (the active substance is toltrazuril), “Koktsifen” (the active substances are toltrazuril, fenbendazole), as well as their combination with the probiotic “ModeS Kombiflor Probiotic” (the active substances are Lactobacillus spp., Bifidobacterium bifidum, Streptococcus thermophilus, Enterococcus faecium, Slovenia) were tested. It has been found that the most effective for the specific therapy of dogs suffering from cystoisosporiasis are “Koksifen” and “Turil® 5%”, which ensure 100.0% extense- and intense-effectiveness, respectively, on the 7th and 14th days of treatment. The complex treatment of dogs with cystoisosporiasis in case of the simultaneous use of the specific preparations “Koksifen” and “Turil® 5%”, as well as the probiotic “ModeS Kombiflor Probiotic” increases the effectiveness of the specific therapy, shortens the recovery period of animals, where the extense- and intense-effectiveness reaches 100.0% on the 4th and 5th days of treatment, respectively. It was determined that the cheapest of the tested treatment regimens for canine cystoisosporiasis was the use of “Turil® 5%” preparation, where the cost of treatment per dog made 14.40 UAH, which is 12.60 UAH less than in case of the application of “Koktsifen” preparation and 154.9 and 167.5 UAH less than in case of the use of the complex therapy, which included the simultaneous use of “Turil® 5%” with “ModeS Kombiflor Probiotic” as well as “Koktsifen” with “ModeS Kombiflor Probiotic”, respectively. The obtained results of determining the economic and therapeutic efficacy of the tested preparations to control canine cystoisosporiasis allow us to recommend the specific drugs “Koktsifen”, “Turil® 5%” and the probiotic “ModeS Kombiflor Probiotic”.
References
1. Buehl, I. E., Prosl, H., Mundt, H.-C., Tichy, A. G., & Joachim, A. (2006). Canine isosporosis – epidemiology of field and experimental infections. Journal of Veterinary Medicine, Series B, 53(10), 482–487. https://doi.org/10.1111/j.1439-0450.2006.00973.x
2. Zhang, Y., Qin, Z., Zhang, K., Lang, J., Wang, N., Niu, Y., & Zhang, L. (2023). Morphological and molecular biology identification of Cystoisospora sp. in the blue fox, Alopex lagopus (Linnaeus, 1758). Parasitology Research, 123(1), 35. https://doi.org/10.1007/s00436-023-08044-6
3. He, P., Li, J., Gong, P., Huang, J., & Zhang, X. (2012). Cystoisospora spp. from dogs in China and phylogenetic analysis of its 18S and ITS1 gene. Veterinary Parasitology, 190(1-2), 254–258. https://doi.org/10.1016/j.vetpar.2012.05.025
4. Idrissi, H., Khatat, S. E. H., Duchateau, L., Kachani, M., Daminet, S., El Asatey, S., Tazi, N., Azrib, R., & Sahibi, H. (2022). Prevalence, risk factors and zoonotic potential of intestinal parasites in dogs from four locations in Morocco. Veterinary Parasitology: Regional Studies and Reports, 34, 100775. https://doi.org/10.1016/j.vprsr.2022.100775
5. Xhaxhiu, D., Kusi, I., Rapti, D., Kondi, E., Postoli, R., Rinaldi, L., Dimitrova, Z. M., Visser, M., Knaus, M., & Rehbein, S. (2010). Principal intestinal parasites of dogs in Tirana, Albania. Parasitology Research, 108(2), 341–353. https://doi.org/10.1007/s00436-010-2067-8
6. Lloyd, S., & Smith, J. (2001). Activity of toltrazuril and diclazuril against Isospora species in kittens and puppies. Veterinary Record, 148(16), 509–511. https://doi.org/10.1136/vr.148.16.509
7. Daugschies, A., Mundt, H.-C., & Letkova, V. (2000). Toltrazuril treatment of cystoisosporosis in dogs under experimental and field conditions. Parasitology Research, 86(10), 797–799. https://doi.org/10.1007/s004360000217
8. Dubey, J. P., & Lindsay, D. S. (2019). Coccidiosis in dogs – 00 years of progress. Veterinary Parasitology, 266, 34–55. https://doi.org/10.1016/j.vetpar.2018.12.004
9. Altreuther, G., Gasda, N., Adler, K., Hellmann, K., Thurieau, H., Schimmel, A., Hutchens, D., & Krieger, K. J. (2011). Field Evaluations of the efficacy and safety of emodepside plus toltrazuril (Procox® oral suspension for dogs) against naturally acquired nematode and Isospora spp. infections in dogs. Parasitology Research, 109(S1), 21–28. https://doi.org/10.1007/s00436-011-2399-z
10. Litster, A. L., Nichols, J., Hall, K., Camp, J., & Mohamed, A. S. (2014). Use of ponazuril paste to treat coccidiosis in shelter-housed cats and dogs. Veterinary Parasitology, 202(3-4), 319–325. https://doi.org/10.1016/j.vetpar.2014.03.003
11. Petry, G., Kruedewagen, E., Kampkoetter, A., & Krieger, K. (2011). Efficacy of emodepside/toltrazuril suspension (Procox® Oral suspension for dogs) against mixed experimental Isospora felis/Isospora rivolta infection in cats. Parasitology Research, 109(S1), 29–36. https://doi.org/10.1007/s00436-011-2400-x
12. Barrera, J. P., Montoya, A., Marino, V., Sarquis, J., Checa, R., & Miró, G. (2024). Cystoisospora spp. infection at a dog breeding facility in the Madrid region: Infection rate and clinical management based on toltrazuril metaphylaxis. Veterinary Parasitology: Regional Studies and Reports, 48, 100971. https://doi.org/10.1016/j.vprsr.2023.100971
13. Garanayak, N., Gupta, A. R., & Patra, R. C. (2016). Successful therapeutic management of canine Isosporosis in puppies. Journal of Parasitic Diseases, 41(1), 48–50. https://doi.org/10.1007/s12639-015-0747-0
14. Wilkinson, G. (1977). Coccidial infection in a cat colony. Veterinary Record, 100(8), 156–157. https://doi.org/10.1136/vr.100.8.156
15. Dunbar, M. R., & Foreyt, W. J. (1985). Prevention of coccidiosis in domestic dogs and captive coyotes (Canis latrans) with sulfadimethoxine-ormetoprim combination. American Journal of Veterinary Research, 46(9), 1899–1902. https://doi.org/10.2460/ajvr.1985.46.09.1899
16. Lindsay, D. S., & Blagburn, B. L. (1995). Practical treatment and control of infections caused by canine gastrointestinal parasites. Veterinary Medicine, 89, 441–455.
17. Tishyn, O. L., Yuskiv, I. D., & Yuskiv, L. L. (2023). Comparative assessment of complex drugs based on toltrazuril and moxidectin and toltrazuril and emodepside for nematodoses and cystoisosporosis of dogs. Scientific and Technical Bulletin Оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives Аnd Institute of Animal Biology, 24(2), 206–215. https://doi.org/10.36359/scivp.2023-24-2.23
18. Melnychuk, V. V., Kitichenko, A. S., Suvorov, R. S., Pohorelova, H. M., Yevstafieva, V. O., & Gudz, N. V. (2025). Sposib koproksopichnoho doslidzhennia sobak na naiavnist yaits zbudnykiv nematodoziv travnoho traktu ta ootsyst tsystoizospor [Method of coproscopic examination of dogs for the presence of eggs of pathogens of the digestive tract nematodes and oocysts of cystoisospores] (Ukrainian Patent No. u202405785). Ukrainian Intellectual Property Institute. https://sis.nipo.gov.ua/uk/search/detail/1861787/ (in Ukrainian)
19. Fadila, K. A., & Kusumarini, S. (2024). Diagnosis, hematologic profile, and treatment of cystoisosporiasis in domestic dog. Jurnal Medik Veteriner, 7(1), 205–211. https://doi.org/10.20473/jmv.vol7.iss1.2024.205-211
20. Ibarra-Velarde, F., Vera-Montenegro, Y., Saldaña-Hernández, N., & Ochoa-Galván, P. (2014). Comparison of the efficacy of two commercial coccidicidal compounds on experimentally infected dogs. Pharmacology & Pharmacy, 5(13), 1163–1170. https://doi.org/10.4236/pp.2014.513127
